منابع مشابه
PTHrP and skeletal development.
Parathyroid hormone-related protein (PTHrP) participates in the regulation of endochondral bone development. After the cartilage mold is established in fetal life, perichondrial cells and chondrocytes at the ends of the mold synthesize PTHrP. This ligand then acts on PTH/PTHrP receptors on chondrocytes. As chondrocytes go through a program of proliferation and then further differentiation into ...
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The limited ability of articular cartilage to repair after traumatic insult or during arthritic degeneration is widely attributed to the fact that the tissue lacks both innervation and vascularisation. However, comparative studies of articular cartilage repair in load bearing and non-load bearing areas of the joint, in addition to some in vitro studies suggest more strongly that adult articular...
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IIntroduction I-1. Developmental genes in Drosophila I-2. Skeletal development in human IIDevelopment of the axial skeleton II-1. Signaling molecules involved in the determination of sclerotome to cartilage II2. Role of Hox genes in the regulation of vertebral segments IIIDevelopment of the limbs (appendicular skeleton) III-1. Limb bud differentiation with respect to three axes III-2. Role of F...
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The fibroblast growth factor receptor family consists of four receptor tyrosine kinases which bind with varying affinity and specificity to a family of at least fifteen polypeptide ligands. The receptors and ligands perform many essential functions during growth, development and repair. Recent discoveries show that a growing number of skeletal abnormalities result from mutations in the fibrobla...
متن کاملMechanostat function during skeletal development.
these genes prevents development of skeletal muscle and mouse pups are born with a skeleton that lacks many of the features seen normally. Bones are straight instead of curved, and lack either the narrowing of the mid-shaft of the cortex or the flaring of the metaphyses seen in WT controls. Even more striking is the absence of the traction epiphyses, proving Julius Wolff’s assertion over 100 ye...
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ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 1977
ISSN: 0032-5473
DOI: 10.1136/pgmj.53.622.429